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Virulence factors are released in association with outer me..:

Chowdhury, Chiranjit ; Jagannadham, Medicharla Venkata
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics.  1834 (2013)  1 - p. 231-239 , 2013
Link: https://doi.org/10.1016/j.bbapap.2012.09.015