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Conserved C272/278 in b domain regulate the function of PDI..:

Miyakawa, Miho ; Zukeran, Gosuke ; Wada, Yuko.
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics.  1854 (2015)  5 - p. 485-491 , 2015
Link: https://doi.org/10.1016/j.bbapap.2015.02.014