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Loss of a water-mediated network results in reduced agonist..:

Nikte, Siddhanta V. ; Sonar, Krushna ; Tandale, Aditi..
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics.  1869 (2021)  4 - p. 140605 , 2021
Link: https://doi.org/10.1016/j.bbapap.2021.140605