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Cryotherapy (ice chips) is effective in preventing melphala..:

Finn, K.T. ; Sanchorawala, V. ; Kunz, R....
Biology of Blood and Marrow Transplantation.  10 (2004)  - p. 86 , 2004
Link: https://doi.org/10.1016/j.bbmt.2003.12.170