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The polyglutamine-expanded protein ataxin-3 decreases bcl-2..:

Tien, Chih-Liang ; Wen, Feng-Chen ; Hsieh, Mingli
Biochemical and Biophysical Research Communications.  365 (2008)  2 - p. 232-238 , 2008
Link: https://doi.org/10.1016/j.bbrc.2007.10.162