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Long-term high glucose concentration influences Akt, ERK1/2..:

Popov, Doina ; Nemecz, Miruna ; Dumitrescu, Madalina..
Biochemical and Biophysical Research Communications.  388 (2009)  1 - p. 51-55 , 2009
Link: https://doi.org/10.1016/j.bbrc.2009.07.141