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Both the Fab and Fc domains of IgG are essential for ROS em..:

Higurashi, Saki ; Machino, Yusuke ; Suzuki, Emiko...
Biochemical and Biophysical Research Communications.  417 (2012)  2 - p. 794-799 , 2012
Link: https://doi.org/10.1016/j.bbrc.2011.12.038