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PKM1 is involved in resistance to anti-cancer drugs:

Taniguchi, Kohei ; Sakai, Miku ; Sugito, Nobuhiko...
Biochemical and Biophysical Research Communications.  473 (2016)  1 - p. 174-180 , 2016
Link: https://doi.org/10.1016/j.bbrc.2016.03.074