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Unstructured loop is essential for the activation of mGluR2:

Singh, Deo R. ; Mishra, Ashish K. ; Pandey, Pankaj...
Biochemical and Biophysical Research Communications.  521 (2020)  3 - p. 775-778 , 2020
Link: https://doi.org/10.1016/j.bbrc.2019.10.187