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An orphan G-protein-coupled receptor causes human gigantism..:

Trivellin, Giampaolo ; Hernández-Ramírez, Laura C. ; Swan, Jeremy.
Best Practice & Research Clinical Endocrinology & Metabolism.  32 (2018)  2 - p. 125-140 , 2018
Link: https://doi.org/10.1016/j.beem.2018.02.004