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Discovery of piperidine carboxamide TRPV1 antagonists:

Cheung, Wing S. ; Calvo, Raul R. ; Tounge, Brett A....
Bioorganic & Medicinal Chemistry Letters.  18 (2008)  16 - p. 4569-4572 , 2008
Link: https://doi.org/10.1016/j.bmcl.2008.07.035