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The discovery of highly potent CGRP receptor antagonists:

Stump, Craig A. ; Bell, Ian M. ; Bednar, Rodney A....
Bioorganic & Medicinal Chemistry Letters.  19 (2009)  1 - p. 214-217 , 2009
Link: https://doi.org/10.1016/j.bmcl.2008.10.106