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Disubstituted pyrimidines as Lck inhibitors:

Hunt, Julianne A. ; Beresis, Richard T. ; Goulet, Joung L....
Bioorganic & Medicinal Chemistry Letters.  19 (2009)  18 - p. 5440-5443 , 2009
Link: https://doi.org/10.1016/j.bmcl.2009.07.102