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Water-soluble PDE4 inhibitors for the treatment of dry eye:

Govek, Steven P. ; Oshiro, Guy ; Anzola, John V....
Bioorganic & Medicinal Chemistry Letters.  20 (2010)  9 - p. 2928-2932 , 2010
Link: https://doi.org/10.1016/j.bmcl.2010.03.023