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Spiroindane based amides as potent and selective MC4R agoni..:

He, Shuwen ; Ye, Zhixiong ; Dobbelaar, Peter H....
Bioorganic & Medicinal Chemistry Letters.  20 (2010)  15 - p. 4399-4405 , 2010
Link: https://doi.org/10.1016/j.bmcl.2010.06.062