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Discovery of oral and inhaled PDE4 inhibitors:

Ting, Pauline C. ; Lee, Joe F. ; Kuang, Rongze...
Bioorganic & Medicinal Chemistry Letters.  23 (2013)  20 - p. 5528-5532 , 2013
Link: https://doi.org/10.1016/j.bmcl.2013.08.056