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Pyridine and pyridinone-based factor XIa inhibitors:

Corte, James R. ; Fang, Tianan ; Hangeland, Jon J....
Bioorganic & Medicinal Chemistry Letters.  25 (2015)  4 - p. 925-930 , 2015
Link: https://doi.org/10.1016/j.bmcl.2014.12.050