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Optimization of amide-based EP3 receptor antagonists:

Lee, Esther C.Y. ; Futatsugi, Kentaro ; Arcari, Joel T....
Bioorganic & Medicinal Chemistry Letters.  26 (2016)  11 - p. 2670-2675 , 2016
Link: https://doi.org/10.1016/j.bmcl.2016.04.009