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Cytochrome P450 2E1 should not be neglected for acetaminoph..:

Massart, Julie ; Begriche, Karima ; Fromenty, Bernard
Clinics and Research in Hepatology and Gastroenterology.  45 (2021)  1 - p. 101470 , 2021
Link: https://doi.org/10.1016/j.clinre.2020.05.018