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Low IGFBP-1 is a marker of impaired skin vascular response ..:

Lehtihet, Mikael ; Jörneskog, Gun ; Alvarsson, Michael...
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.  3 (2009)  2 - p. 103-108 , 2009
Link: https://doi.org/10.1016/j.dsx.2009.04.009