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Loss of K607 and E877 interaction is a key reason for JAK2 ..:

Wu, Qing-Yun ; Ma, Meng-Meng ; Zhang, Sen...
International Journal of Biological Macromolecules.  124 (2019)  - p. 1123-1131 , 2019
Link: https://doi.org/10.1016/j.ijbiomac.2018.11.280