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Tyr320 is a molecular determinant of the catalytic activity..:

Shanmugam, Ramasamy ; Kim, In-Won ; Tiwari, Manish K....
International Journal of Biological Macromolecules.  151 (2020)  - p. 609-617 , 2020
Link: https://doi.org/10.1016/j.ijbiomac.2020.02.117