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An evaluation of the variability of tumor-shape definition ..:

Cooper, Jay S. ; Mukherji, Suresh K. ; Toledano, Alicia Y....
International Journal of Radiation Oncology*Biology*Physics.  67 (2007)  4 - p. 972-975 , 2007
Link: https://doi.org/10.1016/j.ijrobp.2006.10.029