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Genetic variants in HLA are a significant risk factor for p..:

Asai, Yuka ; Al-Eslami, Aida ; Akhabir, Loubna...
Journal of Allergy and Clinical Immunology.  139 (2017)  2 - p. AB88 , 2017
Link: https://doi.org/10.1016/j.jaci.2016.12.238