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Long-term treatment with the pure anti-estrogen fulvestrant..:

Badia, Eric ; Docquier, Aurélie ; Busson, Muriel...
The Journal of Steroid Biochemistry and Molecular Biology.  132 (2012)  1-2 - p. 176-185 , 2012
Link: https://doi.org/10.1016/j.jsbmb.2012.05.006