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FGF21 does not require adipocyte AMP-activated protein kina..:

Mottillo, Emilio P. ; Desjardins, Eric M. ; Fritzen, Andreas M....
Molecular Metabolism.  6 (2017)  6 - p. 471-481 , 2017
Link: https://doi.org/10.1016/j.molmet.2017.04.001