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No-observed effect levels are associated with up-regulation..:

Doak, Shareen H. ; Brüsehafer, Katja ; Dudley, Ed...
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis.  648 (2008)  1-2 - p. 9-14 , 2008
Link: https://doi.org/10.1016/j.mrfmmm.2008.09.016