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Silica nanoparticles administered at the maximum tolerated ..:

Downs, Thomas R. ; Crosby, Meredith E. ; Hu, Ting...
Mutation Research/Genetic Toxicology and Environmental Mutagenesis.  745 (2012)  1-2 - p. 38-50 , 2012
Link: https://doi.org/10.1016/j.mrgentox.2012.03.012