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Histamine may contribute to vortioxetine's procognitive eff..:

Smagin, Gennady N. ; Song, Dekun ; Budac, David P....
Progress in Neuro-Psychopharmacology and Biological Psychiatry.  68 (2016)  - p. 25-30 , 2016
Link: https://doi.org/10.1016/j.pnpbp.2016.03.001