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Doxycycline diminishes the rewarding and psychomotor effect..:

Sales, Amanda J. ; Gobira, Pedro H. ; Pedrazzi, João F.C....
Progress in Neuro-Psychopharmacology and Biological Psychiatry.  128 (2024)  - p. 110870 , 2024
Link: https://doi.org/10.1016/j.pnpbp.2023.110870