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Expression of p16INK4A, p53, and Rb proteins are independen..:

Nemes, Judit A. ; Deli, Levente ; Nemes, Zoltán.
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology.  102 (2006)  3 - p. 344-352 , 2006
Link: https://doi.org/10.1016/j.tripleo.2005.10.069