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p53 is a rate-limiting factor in the repair of higher-order..:

Aranda-Anzaldo, Armando ; Orozco-Velasco, Francisco ; Garcı́a-Villa, Enrique.
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression.  1446 (1999)  3 - p. 181-192 , 1999
Link: https://doi.org/10.1016/s0167-4781(99)00086-x