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Iterative data analysis is the key for exhaustive analysis ..:

Schmidt, Frank ; Schmid, Monika ; Jungblut, Peter R....
Journal of the American Society for Mass Spectrometry.  14 (2003)  9 - p. 943-956 , 2003
Link: https://doi.org/10.1016/s1044-0305(03)00345-3