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1 Ergebnisse
1
Optimization of Orally Bioavailable Enhancer of Zeste Homol..:
Kung, Pei-Pei
;
Bingham, Patrick
;
Brooun, Alexei
...
Journal of Medicinal Chemistry. 61 (2017) 3 - p. 650-665 , 2017
Link:
https://doi.org/10.1021/acs.jmedchem.7b01375
RT Journal T1
Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497)
UL https://suche.suub.uni-bremen.de/peid=cr-10.1021_acs.jmedchem.7b01375&Exemplar=1&LAN=DE A1 Kung, Pei-Pei A1 Bingham, Patrick A1 Brooun, Alexei A1 Collins, Michael A1 Deng, Ya-Li A1 Dinh, Dac A1 Fan, Connie A1 Gajiwala, Ketan S. A1 Grantner, Rita A1 Gukasyan, Hovhannes J. A1 Hu, Wenyue A1 Huang, Buwen A1 Kania, Robert A1 Kephart, Susan E. A1 Krivacic, Cody A1 Kumpf, Robert A. A1 Khamphavong, Penney A1 Kraus, Manfred A1 Liu, Wei A1 Maegley, Karen A. A1 Nguyen, Lisa A1 Ren, Shijian A1 Richter, Dan A1 Rollins, Robert A. A1 Sach, Neal A1 Sharma, Shikhar A1 Sherrill, John A1 Spangler, Jillian A1 Stewart, Albert E. A1 Sutton, Scott PB American Chemical Society (ACS) YR 2017 SN 0022-2623 SN 1520-4804 JF Journal of Medicinal Chemistry VO 61 IS 3 SP 650 OP 665 LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.7b01375 DO https://doi.org/10.1021/acs.jmedchem.7b01375 SF ELIB - SuUB Bremen
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