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Early is superior to deferred preemptive lamivudine therapy..:

Lau, George K.K ; Yiu, Harry H.Y ; Fong, Daniel Y.T...
Gastroenterology.  125 (2003)  6 - p. 1742-1749 , 2003
Link: https://doi.org/10.1053/j.gastro.2003.09.026