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Secreted proNGF is a pathophysiological death-inducing liga..:

Harrington, A. W. ; Leiner, B. ; Blechschmitt, C....
Proceedings of the National Academy of Sciences.  101 (2004)  16 - p. 6226-6230 , 2004
Link: https://doi.org/10.1073/pnas.0305755101