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Targeted disruption of theKcnq1gene produces a mouse model ..:

Casimiro, Mathew C. ; Knollmann, Björn C. ; Ebert, Steven N....
Proceedings of the National Academy of Sciences.  98 (2001)  5 - p. 2526-2531 , 2001
Link: https://doi.org/10.1073/pnas.041398998