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Class IA phosphoinositide 3-kinases are obligate p85-p110 h..:

Geering, Barbara ; Cutillas, Pedro R. ; Nock, Gemma..
Proceedings of the National Academy of Sciences.  104 (2007)  19 - p. 7809-7814 , 2007
Link: https://doi.org/10.1073/pnas.0700373104