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Targeting the ERAD pathway via inhibition of signal peptide..:

Harbut, Michael B. ; Patel, Bhumit A. ; Yeung, Bryan K. S....
Proceedings of the National Academy of Sciences.  109 (2012)  52 - p. 21486-21491 , 2012
Link: https://doi.org/10.1073/pnas.1216016110