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IRAK-1 bypasses priming and directly links TLRs to rapid NL..:

Lin, Keng-Mean ; Hu, Wei ; Troutman, Ty Dale...
Proceedings of the National Academy of Sciences.  111 (2013)  2 - p. 775-780 , 2013
Link: https://doi.org/10.1073/pnas.1320294111