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Doxorubicin cardiotoxicity may be caused by its metabolite,..:

Olson, R D ; Mushlin, P S ; Brenner, D E...
Proceedings of the National Academy of Sciences.  85 (1988)  10 - p. 3585-3589 , 1988
Link: https://doi.org/10.1073/pnas.85.10.3585