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2,3,7,8-Tetrachlorodibenzo-p-dioxin causes an extensive alt..:

Spink, D C ; Lincoln 2nd, D W ; Dickerman, H W.
Proceedings of the National Academy of Sciences.  87 (1990)  17 - p. 6917-6921 , 1990
Link: https://doi.org/10.1073/pnas.87.17.6917