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Human CUL1 forms an evolutionarily conserved ubiquitin liga..:

Lyapina, Svetlana A. ; Correll, Craig C. ; Kipreos, Edward T..
Proceedings of the National Academy of Sciences.  95 (1998)  13 - p. 7451-7456 , 1998
Link: https://doi.org/10.1073/pnas.95.13.7451