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Bioactive rather than total IGF-I is involved in acute resp..:

Brugts, M. P. ; Tjiong, H. L. ; Rietveld, T....
Nephrology Dialysis Transplantation.  25 (2009)  3 - p. 940-946 , 2009
Link: https://doi.org/10.1093/ndt/gfp576