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Charge density studies as a tool in drug design:

Hibbs, D. E. ; Hambley, T. W. ; Johnston, G. A. R..
Acta Crystallographica Section A Foundations of Crystallography.  58 (2002)  s1 - p. c36-c36 , 2002
Link: https://doi.org/10.1107/s0108767302086555