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Pre‐existing IgG antibodies cross‐reacting with the Fab reg..:

Steenholdt, C. ; Palarasah, Y. ; Bendtzen, K....
Alimentary Pharmacology & Therapeutics.  37 (2013)  12 - p. 1172-1183 , 2013
Link: https://doi.org/10.1111/apt.12330